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ATCC
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Bio-Rad
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Santa Cruz Biotechnology
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Proteintech
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Thermo Fisher
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Boster Bio
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R&D Systems
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Developmental Studies Hybridoma Bank
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R&D Systems
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Miltenyi Biotec
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Image Search Results
Journal: Scientific Reports
Article Title: Highly variable biological effects of statins on cancer, non-cancer, and stem cells in vitro
doi: 10.1038/s41598-024-62615-w
Figure Lengend Snippet: The effect of statins on viability and growth of ( a ) stem ADMSC and non-cancerous HEK 293 cells and ( b ) cancer MiaPaCa-2 cells. ( a ) ADMSC—human adipose-derived mesenchymal stem cells, HEK 293—human embryonic kidney cells, exposure to statins—24 h, concentrations 0—100 µM, control—methanol, ( b ) previously published data , MiaPaCa-2—pancreatic cancer cells, exposure to statins—24 h, concentrations 0—40 µM, control—methanol.
Article Snippet: Human adipose-derived
Techniques: Derivative Assay, Control
Journal: Scientific Reports
Article Title: Highly variable biological effects of statins on cancer, non-cancer, and stem cells in vitro
doi: 10.1038/s41598-024-62615-w
Figure Lengend Snippet: Comparison of the effect of statins on the growth and viability of pancreatic cancer MiaPaCa-2 cells, non-cancerous HEK 293 cells, and ADMSC stem cells. Concentration of statins—20 µM, Time—exposure to statins—24, 48, and 72 h, control—methanol.
Article Snippet: Human adipose-derived
Techniques: Comparison, Concentration Assay, Control
Journal: Scientific Reports
Article Title: Highly variable biological effects of statins on cancer, non-cancer, and stem cells in vitro
doi: 10.1038/s41598-024-62615-w
Figure Lengend Snippet: Effect of statins on size and compactness of spheroids. ( a ) ADMSC stem cells, ( b ) pancreatic cancer MiaPaCa-2 cells, concentration of statins—20 µM, Ctr—methanol treated spheroids, P—pravastatin, R—rosuvastatin, L—lovastatin, F—fluvastatin, A—atorvastatin, Pi—pitavastatin, C—cerivastatin, S—simvastatin. Statins were added once, after spheroid formation, 10 weeks ( a ) or 3.5 weeks ( b ) after inoculation. Experiment was carried out in biological dodecaplicates.
Article Snippet: Human adipose-derived
Techniques: Concentration Assay
Journal: Scientific Reports
Article Title: Highly variable biological effects of statins on cancer, non-cancer, and stem cells in vitro
doi: 10.1038/s41598-024-62615-w
Figure Lengend Snippet: Effect of statins on the spheroid formation. ( a ) ADMSC stem cells, ( b ) pancreatic cancer MiaPaCa-2 cells, concentration of statins—20 µM, Ctr methanol treated spheroids, P —pravastatin, R —rosuvastatin, L —lovastatin, F —fluvastatin, A —atorvastatin, Pi —pitavastatin, C —cerivastatin, S —simvastatin. Statins were added once, 24 h after cell inoculation. Experiment was carried out in biological dodecaplicates.
Article Snippet: Human adipose-derived
Techniques: Concentration Assay
Journal: Scientific Reports
Article Title: Highly variable biological effects of statins on cancer, non-cancer, and stem cells in vitro
doi: 10.1038/s41598-024-62615-w
Figure Lengend Snippet: Comparison of expression changes between statin treated and control MiaPaCa-2 and ADMSC cells. Displayed are only the genes that are differentially expressed upon at least one statin treatment in at least one cell type, requiring |log 2 FC|> 1 and FDR < 0.05. Statins were administered at a concentration of 12 µM for 24 h. ( FC fold change, FDR false discovery rate, horizontal and vertical axes—changes in ADMSC and MiaPaCa-2 cells, respectively, upon respective treatment). The red dashed lines indicate two-fold change increase or decrease in the gene expression. The genes with at least two-fold up-regulation (resp. down-regulation) in ADMSC stem cells are displayed to the right (resp. left) of the dashed lines. Similarly, genes with at least two-fold up-regulation (resp. down-regulation) in cancer cells are displayed above (resp. below) of the dashed lines. For details about differentially regulated transcripts see the ArrayExpress database, accessions E-MTAB-3979, E-MTAB-11579 .
Article Snippet: Human adipose-derived
Techniques: Comparison, Expressing, Control, Concentration Assay, Gene Expression
Journal: Scientific Reports
Article Title: Highly variable biological effects of statins on cancer, non-cancer, and stem cells in vitro
doi: 10.1038/s41598-024-62615-w
Figure Lengend Snippet: Cellular pathways most significantly affected by statins in cancer and stem cells. The gene set enrichment analysis (GSEA) revealed the KEGG pathways most affected by statin treatment in ADMSC and MiaPaCa-2 cells. Displayed is the union of the top five most enriched pathways among the comparisons. (Statin concentration—12 µM, treatment time—24 h, p-value—GSEA p-value, gene ratio—fraction of KEGG pathway genes among differentially expressed genes). For details about differentially regulated transcripts, see the ArrayExpress database, accessions E-MTAB-3979, E-MTAB-11579.
Article Snippet: Human adipose-derived
Techniques: Concentration Assay